Five patients were examined (on admission to the hospital) directly into a state of intoxication caused by consumption of 6.8 capsules tramodol. It was noted: motor and language stimulation, increased contact, sociability, cheerfulness, talkativeness, mobility. It was fast, loud, incoherent, but distinct. However, the patients were Sintonen quite nicely captures the mood of the interlocutor, to understand jokes, respond to them. There has been intense gestures.

Observed following the direct autonomic manifestations tramodol intoxication: hyperemia of face, lower blood pressure to an average of 109 ± 5 mm Hg. Art., a slight tachycardia (up to 86 ± 8 beats per minute), reducing the reaction of pupils to light.

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According to the patients know that the systematic use of tramadol is accompanied by abdominal pain and constipation. Many patients do not detailing, complained of discomfort in the retrosternal area, said that “bad had happened to my heart.

All patients reported that despite the occasional use of Tramodol is also used other intoxicants: tranquilizers, drugs cannabis, opiates handmade. Very often to enhance drug of tramodol combined with its reception of a number of benzodiazepine tranquilizers.

Those who use predominantly tramodol, noted the growth of tolerance: from two to three capsules tramodol day (0,05) at the beginning of anesthesia, to twenty of these capsules a day at the time of inspection.